Downstream of these genomic approaches, it is now essential to be able to perform functional studies targeting those candidate genes in order to understand their biological role, for example in the self-renewal process, by acquiring a stable expression of their corresponding cDNAs in a significant proportion of cells among the total population.
Possible biological roles for nonheptad inserts are discussed.
This finding immediately suggested a biological role for the orphan selD genes, as there are a few known examples of enzymes with a labile selenium atom, which is contributed not by SeCys but through some unknown mechanism.
This study points out a novel biological role for TSLP.
Further work is needed to elucidate potential biological mechanisms; for example, the role of chronic inflammation (Smedby et al, 2008; Chang et al, 2010).
DOI: http://dx.doi.org/10.7554/eLife.05322.002 Protein (de)acetylation plays critical roles in many key biological processes, for example, transcriptional regulation, aging, and metabolism (Cohen et al., 2004; Grunstein, 1997; Lin et al., 2009; Lu et al., 2011).
For example, the biological roles of AQs such as DHQ or the N-oxide derivatives in P. aeruginosa remain to be elucidated, as are the functions of AQs in other pathogenic and beneficial microorganisms producing them.
Tanks could play a much larger role, for example.
Many researches have demonstrated that homo-oligomerization is an essential function for biological activity and play an important role in a wide range of biological processes, for example, signal transduction, gene expression regulation, enzyme activation and immune response [2 6].
miRNAs are some of the key regulators of various biological processes, for example, they play an important role in virus-host interactions [ 2- 4].
