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Further, we examine the effect of receptor dimerization patterns on biological response using a simple phenomenological model.
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However, the concentration of IL-11 required to mediate a biological response using sIL-11Rα had to be 10- 20-fold higher than using membrane receptor [ 11].
Comparing baseline gene expression levels and biological response using the average of these 15 genes revealed a significant negative correlation (R = −0.7208; p = 0.0016) (figure 2B).
Other conventional assays include determining T‐cell biological response using skin reactions to vaccine antigens (i.e., delayed‐type hypersensitivity).
For characterisation purposes, we determined smoke deposition in relationship to airflow (L/min), regional smoke deposition within the linear exposure module, vapour phase dilution using a known smoke marker (carbon monoxide) and finally assessed biological responses using two independent biological systems, the Ames and Neutral Red uptake (NRU) assay.
The range 1 : 5–1 : 400 was selected as this represents the RM20S dilutions used in the laboratory to generate a biological dose response using robust in vitro primary and continuous cell cultures [ 1, 7, 9].
The development of a systematic approach to explore whether a given toxicological response does exhibit a biological threshold using a key events dose-response framework based on the mode of action responds to this concern.
To obtain a broader understanding of the effects of dichlorvos on liver metabolism, we performed a genome-wide analysis of gene expression in the liver of zebrafish exposed to DDVP and identified biological responses to DDVP using a functional analysis of differentially expressed genes.
Demonstration of a multimodal nanotherapeutic system and inclusion of the biological response to radiation using an in vitro/in vivo tumor model incorporating characteristics of tumor microenvironment presents an advance in preclinical evaluation of existing and novel cancer nanotherapies.
In addition, we have used carbon monoxide as a vapour phase marker of whole smoke and finally, produced repeatable biological dose-responses using two independent in vitro systems.
Improved prediction of treatment response using microarrays and existing biological knowledge.
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