Owing to the above explanations, we had reasons to expect biological relations between levels of the components of the plasminogen activating system, especially PAI-1, and the angiogenic process.
Finally, in order to investigate the biological relations between the 179 literature-collected and 43 network-predicted genes, we repeated the pathway analysis in DAVID (using the same procedure previously described) considering the 222 (179 + 43) candidate genes.
On the other hand, it cannot identify particular components responsible for an energy-dense diet and thus is less informative in terms of biological relations between individual dietary components and disease risk.
To study the biological relation and functional diversity between the individual network components, we cluster the network components according to the results of the Gene Ontology enrichment analysis from the category Cellular Component.
Interfaces are defined biological relations, like the link between heart and lung, while interactions describe non-designed but inevitable biological consequences of being a mechanism with a single source of energy.
Note that, the previous temporal dynamic model needs multiple datasets to deduce causal relation between biological processes [ 13], however, our CPM can infer meaningful functional cascade dynamics during biological transitions even on single dataset.
TSRs can also be linked to biological functions as we have shown a strong relation between TSR-related gene clusters and biological coherence in terms of functionality as well as cellular localization (Figures 2 and 3).
Proposals should cite a direct relation between biological applications and mathematics, and research teams should include representatives from both life sciences and mathematics.
The correlation analysis indicates a negative relation between biological activities (microbial biomass carbon, dehydrogenase, urease, and phosphatase activity) and residual concentrations of Ph and Py in planted soils.
