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However, NaV1.8 antisense-mediated inhibitory effects might not generate same biological regulations in all other inflammatory pain models.
In addition, results from gene ontology (GO) analysis showed that CNVs identified in this study were enriched in the pathways of cell parts, protein binding, developmental processes, biological regulations, and cell communication in the GO category (Table S2).
However in reality, biological regulations, both instantaneous and time-delayed, occur simultaneously.
Undoubtedly, discovery of pathway cross-talks is indeed important for understanding biological regulations, but we may face several challenges.
In the present paper we study simpler models, which pertain to basic network motifs found in biological regulations.
Finally, like most gene set-based analysis, eGSA counts the contribution of each gene in biological regulations equally.
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GO analysis suggested that proteins involved in metabolic process, stimulus response and biological regulation were regulated after acupuncture intervention.
Additionally, a fraction of DEGs were associated other important processes, including transcription regulator, transport, biological regulation and response to stimulus.
Most biological regulation systems comprise feedback circuits as crucial components.
Candidate genes classified in biological regulation and localization (six transporters) were found within QTLs.
Enzymes are fundamental biological catalysts responsible for biological regulation and metabolism.
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