Sentence examples for biological readout from inspiring English sources

Finally, to corroborate the significance of these results, we tested if the small expression gain elicited by our saRNAs led to an appreciable biological readout.

The results showed the nature of the spacer influences the biological readout.

Although calcium transient patterns in the egg are highly indicative of developmental outcomes, monitoring these transients requires intracellular imaging dyes and thereby prohibits the clinical application of this biological readout.

A drug's mechanism of action may refer to its effects on a biological readout such as cell growth, or its interaction and modulation of its direct biomolecular target, for example a protein or nucleic acid.

Leukemic stem cells tend to group together to form structures called cobblestones, which Hartwell describes as "a biological readout of stemness". By evaluating the number of cobblestone formations, the team can find drugs that interfere with the activity of cancer stem cells.

"Maybe there are nuances to the way this is done so that, in some laboratories, the technology has a different biological readout than in other laboratories".

To illustrate the utility of the bioreactor, we present a "case study" of hESC cultivation with detailed experimental methods and representative biological readouts.

This is in contrast to the potential receptor cross-reactivity towards closely related peptides and variable dose responsiveness seen in biological readouts.

The over-expression of these peptides can revert the phenotype of K-RAS transformed mouse fibroblasts to wild type, as monitored by several independent biological readouts, including Ras GTP intracellular levels, ERK activity, morphology, proliferative potential and anchorage independent growth.

We propose that this methodology can robustly discern minute changes in stem cell states within complex 3-D architectures and map single cell biological readouts that are critical to assessing population level cell heterogeneity.

This device allows the use of co-registered small-animal PET MRI images to guide the movements of robotic controllers, which will accurately place a needle probe at any predetermined location inside, for example, a mouse tumor, for biological readouts without sacrificing the animal.