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End-stage failing heart valves are currently replaced by mechanical or biological prostheses.
Finally, the development of biological prostheses for percutaneous mitral valve replacement is at an early stage.
Mechanical and biological prostheses are used to replace damaged heart valves but are associated with significant morbidities.
Heart valve tissue engineering could be a possible solution for the limitations of mechanical and biological prostheses, which are commonly used for heart valve replacement.
While allogenic and xenogenic biological prostheses are related to graft rejection, degeneration and thrombosis, resulting in a high rate of reoperation.
However, a fundamental problem inherent to the use of existing mechanical and biological prostheses in the pediatric population is their failure to grow, repair, and remodel.
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This trial is evaluating the long-term safety and effectiveness of the Model 400 Aortic Valve Biological Prosthesis in patients who require replacement of the aortic valve.
The St Jude Medical Inc Stt Paul, Minn) Trifecta valve is a novel aortic biological prosthesis that incorporates several design features, including a true supra-annular sewing cuff, a stent design that maximizes valve hemodynamics while minimizing leaflet stresses, and an ethanol-based anticalcification technology.
The use of current available biological cardiac prostheses such as glutaraldehyde fixed xenovalves and aortic or pulmonary homografts is unfortunately limited by several reasons.
Further developments towards the alternative biological valves prostheses based on biological cell-free matrices as ideal valve substitute using methods of tissue engineering would potentially abolish the known disadvantages of current valve prostheses.
Mechanical and biological heart valve prostheses which are recently used have several shortcomings.
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