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"The trial did provide a biological proof of concept, he said.
The third idea is that the brain provides biological proof of our experiences.
Hence we undertook an effort to design both inhibitors and activators using structure-based drug design techniques and report here the biological proof of concept.
As biological proof of concept that early aortic wall apoptosis plays a role in aneurysm development in Marfan syndrome, Fbn1(C1039G/+) mice were treated daily from 2 to 6 weeks with either (1) a pan-caspase inhibitor, Q-VD-OPh (20 mg/kg), or (2) vehicle control intraperitoneally.
"Many practitioners of acupuncture have observed that this ancient practice can reduce stress in their patients, but there is a lack of biological proof of how or why this happens.
These data provide a biological proof of concept with spatial and temporal scaffold level variations observed.
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Our plan for achieving this aim was to: (i) obtain in vitro and in vivo biological proof-of-principle data with a large and commercially available polyamidoamine (PAMAM) dendrimer that we could glycosylate; (ii) identify and make a novel, much smaller and simpler glycosylated dendrimer that had better in vitro and in vivo bioactivity over a longer period of time.
He calls finding this kind of strong biological proof phase zero a necessary step before the expensive Phase I, II and III gamut of clinical trials all medicines must run and demands it of new Sanofi products.
RNA 2: Clustering by Gene or Condition and Other Regulon Data Sources Nucleic Acid Motifs; The Nature of Biological "proofs".
Researchers basically work with what we layfolk tell them about our dreams, rather than any biological or concrete proof of dreams' existence, which makes it hard for sleep experts to perfect the science of when ― and how often ― we dream.
One candidate drug class to prevent organ dysfunction in at-risk patients are statins, for which biological plausibility and proof of concept data exist for salutary effects on infection-related inflammatory response [ 12, 13].
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