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Elucidating the molecular mechanisms controlling many biological processes will be supplemented by information to be obtained from other technologies such as proteomics, metabolomics (Okazaki and Saito 2016), epigenomics (Chen and Zhou 2013), and phenomics (Yang et al. 2013).
It is unlikely that gene regulatory networks which are sufficiently accurate to make quantitative predictions on the underlying biological processes will be available in the near future [15], [16].
In subsequent sections, a few relevant biological processes will be dissected in some detail.
For simplicity these models that consist of networked fuzzy biological processes will be called of Bionet models.
These biological processes will be developed with evolved understanding and continued investigation of cellular and molecular mechanisms [ 34], which could be further research interests in the field.
We therefore believe that increasing the size and heterogeneity of the test compound library as well as comparing the toxicity data obtained in several assays for key biological processes will be a successful strategy to overcome the lack of positive controls for DNT/DT.
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Only the GO terms in the category biological process will be considered below; the complete results are available in Supplementary Table S8.
This will also ensure that no "place holder" root GO terms (molecular function, cellular component and biological process) will be selected for those genes where annotations already exist along the corresponding paths in the GO graph.
As with PCBs, chiral OH-PCB formed by abiotic processes will be racemic, whereas OH-PCBs in biological samples will be nonracemic due to atropselective biological transport and biotransformation processes.
It is likely that several different biological process will coordinate to regulate lifespan, and that different processes will be pertinent in specific situations.
"In the longer term, we expect that biological processes will ultimately be too complex to be more than superficially 'understood' in the classical sense.
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