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Many of the physical and biological processes that characterize arctic ecosystems are unique to high latitudes, and their sensitivities to climate change are poorly understood.
Genome-wide profiling of breast cancer tumors and cell lines are continually used to identify dysregulated biological processes that characterize the etiology and progression of the disease at the molecular level.
Employing a systems biology approach, we have identified for the first time the transcriptional profiles and corresponding biological processes that characterize the scope of ARI symptoms amongst four clinically distinct groups.
Motivation: Analyzing data from multi-platform genomics experiments combined with patients' clinical outcomes helps us understand the complex biological processes that characterize a disease, as well as how these processes relate to the development of the disease.
A summary of the results from this study showing the genes, pathways and biological processes that characterize the key molecular events in clinically prion infected mouse brain is provided as a schematic in Figure 7. Microarray experiments have been performed on tissues affected by many diverse diseases in efforts to document the changes in tissues at the transcriptional level.
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The purpose of this analysis was to find important biological functions and processes that characterize the impact of the DEGs identified in this study.
The scientific community faces an ongoing challenge in the analysis of these rich data sources to more accurately characterize biological processes that have been perturbed at the mechanistic level.
To characterize the biological processes that may be occurring within each cell type, and therefore to better understand their function, Gene Ontology analysis of the biological processes to which each enriched gene contributes was carried out (Additional file 6).
To further characterize the biological processes that might be affected in Twin-DS-iPSCs, we investigated the functional annotations associated with the 1204 differentially expressed genes using DAVID (Database for Annotation, Visualization and Integrated Discovery).
However, to understand the underlying mechanisms of gastric tumorigenesis, it is essential to characterize the biological processes that initiate the development of GC and its subsequent progression, especially, to document the gene expression pattern from a high-risk population of GC.
By integrating biological knowledge, we want to identify the biological processes that best reflect the molecular changes characterizing the conditions under study.
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