Despite the large evolutionary distance and extensive rewiring of individual interactions, both networks retain conserved features and display similar levels of functional crosstalk between biological processes, suggesting general design principles of genetic interactomes.
Each set of forward- and reverse-subtracted organ cDNA libraries consisted of a distinct gene list and corresponding distribution of biological processes, suggesting that transcript profiles of these libraries were highly organ-specific.
Recently, accumulating data reveal that O-GlcNAcylation at histones or non-histone proteins can lead to the start of the subsequent biological processes, suggesting that O-GlcNAcylation as 'protein code' or 'histone code' may provide recognition platforms or executive instructions for subsequent recruitment of proteins to carry out the specific functions.
"General" kinase genes had associations with many diverse biological processes, suggesting a group of kinases with many different functions.
This multi-scale perspective on biological networks, examining relationships between the elementary parts as well as "modules" in the form of biological processes suggests a promising new direction for developing a deeper insight into biological function.
Furthermore, individual protein domains of STRUBBELIG cannot be related to specific STRUBBELIG-dependent biological processes suggesting that process specificity is mediated by factors acting together with or downstream of STRUBBELIG.
Gene Ontology analysis found significant enrichments for sets of genes involved in several biological processes, suggesting several possible changes in the phenotype of Dicer-null NS cells (Fig. 4F; full details of the GO analysis are included in Table S3).
Individual reports have shown that lysine acetylation is also involved in other diverse biological processes suggesting a broader regulatory function.
Downregulated prostatitis candidates also had increased percentages of proteins involved in regulation of biological processes, suggesting that while some regulatory proteins increase during prostatitis, others decrease.
The putative targets of these tissue-preferential miRNAs were involved in various metabolism and biological processes, suggesting complexity of the regulatory networks in different tissues.
