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We identify specific biological processes perturbed by TCDD exposure.
Of note, a good overlap of biological processes perturbed by either doxorubicin or etoposide was observed, highlighting the similarity in their mechanism of action in cytotoxicity.
Gene sets with significant NESs (NESs with FDR ≤0.05) for at least one post-exposure time and similar functions were grouped together to represent specific biological processes perturbed by CS.
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This study proposes that cell communication and cell death are major biological processes perturbed in risk of breast cancer conferred by low-penetrance variants, and defines the common omic properties, molecular interactions and possible functional effects of candidate genes and proteins.
Systems approaches are likely to help elucidate the mechanisms underlying the fundamental biological processes perturbed in human diseases and, in doing so, enable more efficient therapeutic interventions.
Ray et al. identified 6 coexpressed gene modules, each of which represented some biological processes perturbed in the HIP of AD brain [ 7].
When we analysed the common DE genes between the dose 0 10 cGy and dose 0 100 cGy comparisons at time 0 h (5 min post radiation), we found a wide range of biological processes perturbed, but with no specific processes dominating.
Given the pivotal role of mTOR in maintaining cellular and organismal homeostasis by controlling multiple fundamental biological processes, perturbing the balance in mTOR signaling might be key to better understanding the Aβ-related impairment in signaling involved in the synaptic dysfunction that characterizes AD.
Also, these studies have been limited to identifying genes and cellular processes perturbed by prion disease and have not exploited these findings to reconstruct dynamical biological networks representing temporal activation of these processes and their interactions.
Nevertheless, the dynamics and coordinate regulation of processes perturbed by excess dietary fat in other organs is scarcely understood.
This aspect is fundamental, especially given the practical impossibility of constructing networks models capturing all of the biological processes potentially perturbed in a given experiment.
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CEO of Professional Science Editing for Scientists @ prosciediting.com