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The biological processes modulated by the presence of DNA repair intermediates include protein synthesis, protein targeting, amino acid biosynthesis, and chromatin assembly.
Notably missing from the list of biological processes modulated by endogenous DNA damage are (i) the 26S proteasome, (ii) lipid metabolism machinery, and (iii) RNA processing machinery.
Notably lacking from the biological processes modulated by DNA repair intermediates is that of the protein degradation machinery (e.g. 26S proteasome) which is robustly induced upon exposure to exogenous DNA damaging agents; this suggests that the trigger for upregulating the proteasome emanates from damaged molecules other than DNA, most likely from damaged proteins.
Among the many biological processes modulated by SPARC, its anti-adhesive [18], [19], pro-migratory [20], and anti-apoptotic [21] properties on certain cell types in addition to its capacity to regulate matrix metalloproteinase (MMP) expression and activity [17], [22], [23] have been associated with increased tumor agresiveness.
Further interpretation was based on the use of different gene annotation databases (GO, KEGG and Ingenuity databases) highlighting numerous biological processes modulated by fasting.
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Gene Ontology analysis to identify biological processes likely modulated by the DEGs was performed in DAVID tools [ 40].
Many important biological processes are modulated by DNA methylation including regulation of gene expression [ 1], development [ 2], and control of retrotransposon elements [ 3].
Fibrosis is a reactive process modulated by various factors propagated by an inflammatory tissue reaction.
MicroRNAs (miRNAs) are endogenously expressed, small, non-coding RNAs that regulate a variety of biological processes by modulating gene expression at the post-transcriptional level [8].
Therefore, our lego-like AuNP gene delivery system can be used universally to control different biological processes by modulating nuclear gene expression events in living systems.
Mature miRNAs exhibit robust regulatory roles in almost all biological processes by modulating the expression of their target genes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com