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Functional analyses of all DEGs highlighted the protein ubiquitination pathway and DNA damage response (DDR) network being the two main biological processes in common in the two cell types.
The question then is why some tissues had more affected biological processes in common.
The kidney medulla-liver and liver-spleen tissue combinations had the fewest number of biological processes in common with only three and five processes, respectively.
Interestingly, the groups receiving 13 and 260 kBq shared the largest number of transcripts, but with no affected biological processes in common.
These findings also suggest that both YPR013C and YPR015C have biological processes in common, in addition to their own regulatory pathways.
In contrast, the network comparisons to the TRN have the biological processes in common that are involved in the regulation of gene expression and biosynthetic and metabolic processes.
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Interestingly, immune response was the only biological process in common for all investigated tissues.
Relevant networks analysis revealed bovine miRNAs with coordinated expression that were likely to participate in common biological processes in adipose tissue.
Simultaneous detection of several biological processes in vivo is a common requirement in biomedical and biological applications, and in order to address this issue the use of multiple fluorophores is usually the method of choice.
In particular, it was found that related diseases (gene-based association) might arise due to dysfunction of common biological processes in the cell (34).
Future experiments should reveal if cis and trans RET signaling contribute towards common biological processes in other cell types inside the body as well.
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Justyna Jupowicz-Kozak
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