Metastasis is a complex, multi-step biological process characterized by distinct, interrelated steps that vary in their timing and efficiency [ 1, 2].
The prevailing hypothesis concerning the biological importance of tumor budding is that it represents an epithelial-mesenchymal transition, a biological process characterized by increased migratory capacity and invasiveness [ 25].
Aging is an inevitable biological process characterized by progressive functional decline of all organ systems with simultaneous increase in oxidative damage as a result of reactive oxygen species (ROS) accumulation.
Many biological processes are characterized by allometric relations of the type Y = Y0Mb between an observable Y and body mass M, which pervade at multiple levels of organization.
It is well known that a lot of biological processes are characterized by periodic rhythms as a result of nonlinear cellular regulation, such as the aforementioned circadian rhythms in mice, cell division [3], and complex cell cycles in some organisms [4], [5].
These biological processes are characterized by two regulations, +CLB6 -> -CLB1 and +CLB6 -> -CLB2, and these are included in the regulation list found by GeneNetFinder (Table 1).
The TRIM gene family encodes proteins involved in a broad range of biological processes and characterized by the presence of the tripartite motif (hence the name TRIM), which consists of a RING domain, one or two B-box motifs and a Coiled- coil region (RBCC) [ 1, 2].
This is in accordance with the literature, since aging is an inevitable biological process and characterized by a general decline in physiological function [ 36, 37].
