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miRNAs play critical roles in many biological processes by repressing gene expression at the post-transcriptional level through binding usually at the 3'-untranslated region of the target mRNA [3], [4].
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MicroRNAs (miRNAs) represent a newly identified class of non-protein-coding ~ 22 nt small RNA which plays important roles in multiple biological processes by degrading targeted mRNA or repressing mRNA translation.
Identify over-represented biological processes by means of enrichment analysis.
(E ) Enrichment of GO biological processes by DAVID.
Using PubGene process associations, we annotated all 37 genes to biological processes by probabilistic scoring.
The miRNAs modulate complex physiological and pathological processes by repressing the expression of multiple proteins.
Thus, SIRT1 possibly represses extensive DNA damage response to fine-tune HR repair process by repressing H2AX over-activation.
Coagulation is the biological process by which blood forms clots.
3 4 In recent years, lncRNAs have attracted increasing scientific interest and are believed to be implicated in diverse biological processes, 5 by promoting or repressing transcription, 6 or by acting as modulators of mRNA translation.
To understand the biological processes represented by these genes, we looked for functional enrichment among induced and repressed genes using FunCat.
The gene sets from the C2 data base are separated in 2 categories: CP canonical pathways- canonical representations of biological processes compiled by domain experts) and CGP (chemical and genetic perturbations- gene set representing genes induced or repressed by the perturbation) (http://www.broad.mit.edu/gsea/msigdb/collections.jsp C2).jsp C2
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