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Response networks are typically interpreted by computing which biological processes are enriched in them.
As an example of the strong resemblance in transcriptional system regulation between human and mouse, Figure 4 shows that identical biological processes are enriched and similarly controlled in one direction (human TSR1 vs. mouse TSR2).
GOrilla uses hypergeometric statistics to determine whether particular biological processes are enriched within any ranked input set of genes.
For example, the most pathogenic biological processes are enriched in terms associated with protein localization, cell proliferation and tissue development, all aspects related to disease and particularly cancers.
In addition, we observed that the pigmentation relevant GO Biological Processes are enriched in 422 protein-coding genes, including 'pigmentation during development'pigmentationion' and 'regulation of pigmentation during development' (Supplementary Table S4).
Genome-wide, there appears to be regional variation in levels of structural polymorphism, and functional term analysis revealed that a variety of biological processes are enriched in our data set.
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A total of 235 biological processes were enriched in AR-5s, 306 were enriched in IVBs and of these, 38 were common to both cell types.
Gene ontology (GO) enrichment tests have revealed gene categories belonging to several biological processes were enriched among the negatively selected genes (Additional file 8).
Biological processes were enriched from significantly regulated transcripts (based on Gene Ontology (GO) terms) and then grouped into categories and subcategories of associated cellular function based on GO ancestor charts (http://geneontology.org).org
No biological processes were enriched among the 95 genes.
Fifteen biological processes were enriched by TB exposure (Fisher's Exact test, p < 0.05).
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