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Currently, a wide variety of new medical imaging techniques produces important information about physiology, metabolism, molecular biological processes and functional genomics.
These annotations were then grouped according to biological processes and functional categories (Table 1).
Although multiple technical and biological differences exist between these two studies, a literature-aided meta-analysis [5] on these data, indicated several common biological processes and functional concepts to be associated with the observed differentially-expressed genes in these two studies.
Now, in the post-GWAS era, a major task is to decipher the biological processes and functional mechanisms underlying these associations.
Using the newly developed LNS metric, we found that patterns of expression-level divergence vary among different biological processes and functional groups.
Therefore, besides the prioritization of candidate genes for a disease of interest, it is also of great importance to identify protein complexes underlying a query disease, thereby shedding light on biological processes and functional mechanisms of the occurrence and development of the disease under investigation.
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We have annotated localization, biological process and functional class of proteins by mapping gi accession numbers to HPRD accession numbers [ 56].
Our comprehensive microarray analysis of seedling and flag leaves of rice provided an overview of the rice diurnal transcriptome and indicated some diurnal regulated biological processes and key functional pathways in rice.
The latter genes were analysed further using DAVID tools (Functional Annotation Bioinformatics Microarray Analysis) (http://david.abcc.ncifcrf.gov) (Huang da et al, 2009a; Huang da et al, 2009b), to identify enrichment in Gene Ontology biological processes and in functional pathways (Supporting Information Table S2).
We then performed a Gene Ontology (GO) analysis to cluster genes into functional classes according to GO biological processes and molecular functions and selected the functional classes overrepresented among the differentially expressed genes (GO term enrichment).
The functional categories scrutinized are biological processes and molecular functions as defined in the Gene Ontology Consortium database (http://www.geneontology.org)[49].
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biological pathways and functional
biological domains and functional
biological networks and functional
biological properties and functional
biological interactions and functional
biological activities and functional
biological characteristics and functional
biological processes and Molecular
biological effects and functional
biological themes and functional
biological studies and functional
biological processes and disease-related
biological processes and historical
biological processes and clinical
biological markers and functional
biological data and functional
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