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Amongst the downregulated genes following IL-28A stimulation, those involved in the biological process of mRNA transcription regulation were especially enriched (p = 1.2×10−6; Table 5; Fig. S2A).
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DE miRNAs revealed the participation of additional cellular components (eg. ion channel, actin cytoskeleton, tight junction) and biological processes (cell adhesion, tissue/embryonic development, learning), which also concurs with biological processes of mRNA.
Downregulated mRNAs were prone to be found in pathways of regulation of actin cytoskeleton and pathways in cancer, and upregulated mRNAs contributed to the biological processes of ribosomes and spliceosomes.
Evolutionary analysis in 62 different species showed that RBPs are highly conserved compared to Non-RBPs (p < 2.2e-16, Wilcox-test), reflectheg the conservation of various biological processes like mRNA splicing and ribosome biogenesis.
Over-representation of these diverse biological processes in the mRNA movement provided additional evidence to support that mRNA exchange in these in vitro grafts was extensive and on a genome-wide scale.
In parallel, gene expression data were obtained to provide another view of the underlying biological processes at the mRNA level.
A bioinformatic analysis consisting of protein/gene-protein/gene interaction networks, annotation of biological processes, and microRNA-mRNA interaction indicated that NEK2A directly or indirectly interacts with a number of genes, proteins, and microRNAs [ 80].
Highly represented in the parous breast were biological processes involving both mRNA and RNA metabolic processes and RNA splicing machinery.
From a biological point of view the local feedbacks describe different mechanisms including not only feedback regulation, but also the important process of mRNA-degradation.
The process of mRNA-tRNA translocation.
Biological Process Annotation of 100% id groups.
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