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The complicated biological process may involve chondrocyte hypertrophy, angiogenesis, absorption of original tissues in the suture, and the formation of skeletal matrix.
According to their number and location, it has become evident that a biological process may involve multiple miRNAs, and that a given gene may be regulated by more than one miRNA.
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A single model component may represent a whole set of biological concepts (e.g. there are numerous processes involved in protein degradation, which is generally modelled as a single entity), while one biological process may require multiple model components (protein production involves transcription, translation and mRNA degradation components).
This process may involve the L[T/S]×E motif.
Given that genes annotated to the similar biological process may be involved in the same manually curated pathway, we grouped genes based on the pathway information, and on these gene groups we evaluated InteGO2.
The purpose of this study was to identify which biological processes may be involved in normal labor.
These results highlight that these biological processes may be involved in transition of pigment cell progression to cancerous state.
The biological system is a complex network, and even genes involved in the same biological process may not be correlated [ 6- 8].
Similarly, a number of genes involved in the same biological process may show coordinated regulation in order to respond effectively to biotic and abiotic stresses.
In the context of a biological system, modest changes in the levels of a large number of proteins involved in a particular pathway or biological process may be more meaningful than large changes in a small number of proteins.
Because the transcripts that are involved in biological processes may be upregulated or downregulated, a signed network was created that allowed modules to contain positively and negatively correlated genes in different modules.
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