What sets the new synthetic insecticides apart is their enormous biological potency.
Kralli, A., Bohen, S. P. & Yamamoto, K. R. LEM1, an ATP-binding-cassette transporter, selectively modulates the biological potency of steroid hormones.
Biological evaluations demonstrate that multiple structural features control the biological potency.
Our results show that the biological potency and epigenetic state of in-vitro-reprogrammed induced pluripotent stem cells are indistinguishable from those of ES cells.
This structural manipulation contributes to increased target specificity, enhanced biological potency, improved pharmacokinetic properties, increased functional potency, and lowered metabolic susceptibility.
Altering the sugar moiety could generate novel drugs, which could have different biological potency than daunorubicin and doxorubicin.
With the information harvested from the profile, a genetic evolution procedure was run to improve the biological potency of a peptide population generated randomly from the LHB.
Thus, γ-lactam analogues with methoxy, trifluoromethyl groups of ortho-, meta-, para-positions of cap group were prepared and evaluated their biological potency.
One such ligand is Sonic hedgehog (Shh), whose posttranslational lipid modifications and assembly into multimers enhance its biological potency, potentially through receptor clustering.
Furthermore, to support the biological potency of the compounds, in silico molecular docking studies were carried out against the E. coli MurB (PDB code: 2MBR) and Jnk1 inhibitor (PDB code: 3v3v) enzymes.
Futhermore, Mannich bases have been associated with increased biological potency [28].
