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In a broader sense, implementation of these concepts for fuel production may extend to a number of commercially important biological platforms depending on the potential sources of synthesis gas or its conversion products, namely, volatile fatty acids.
However, both biological platforms exhibit important drawbacks (mainly associated to intracellular retention of the product, lack of post-translational modifications and conformational stresses), that cannot be overcome through further strain optimization merely due to physiological constraints.
To expedite this process, biological platforms that better reflect the intravascular environment in humans will be required in order to shorten drug development time, enable better determination of dosing regimes, and aid in the design of clinical studies.
This renders most biological platforms incompatible with the fabrication and materials processing methods that have been developed and optimized for functional electronics, which are typically planar, rigid and brittle.
In this seminar I will discuss the design and application of non-invasive in vivo molecular MRI as a means to quantify and integrate biological phenomena and diagnostic measures across multiple physical scales (i.e. from the level of gene expression up to whole organ characterization) and biological platforms (i.e. from pre-clinical models to clinical populations).
An engineered reversal of the β-oxidation cycle (r-BOX) and the fatty acid biosynthesis (FAB) pathway are promising biological platforms for advanced fuel and chemical production in part due to their iterative nature supporting the synthesis of various chain length products.
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Our hydrogel system demonstrates a bimodal enzymatically degradable biological platform that can mimic native cellular processes in a temporal manner.
Ambivalence, oscillation, and plain incoherence further result from the overlay of the biological platform with a cloudy blend of recognition and misapprehension where our own long-term rational interests are concerned.
The cell-surface display system serves as an inherent biological platform for immobilizing enzymes, and thus offers three main advantages: (1) no protein diffusion into surrounding media; (2) enhanced biomass hydrolysis stemming from the close proximity, and induced synergy of enzymes present; and (3) easy recoverability and reusability by simple sedimentation or centrifugation.
Based on current technologies and the biological platform for producing cellulosic biofuels, increasing the polysaccharide to lignin ratio is one possible route to increasing biofeedstock quality.
The identified action of neuroglobin in rendering cytochrome c apoptotically inactive provides a unique biological platform on which we can base the design of targeted therapies against a number of neural diseases.
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