Exact(2)
With the development of cheminformatics, more precise associations between ADRs and biological pathways will be identified.
Methods, such as DNA microarrays, which sample many different biological pathways will be useful in defining these novel, multi-faceted defects.
Similar(58)
To conclude on a constructive note, we do believe that an expression-based prognostic method that is knowledge-based, i.e. one that incorporates also well-established biological and clinical information on relevant pathways, will be able to improve current prediction capabilities.
Identification of early, driving key events in toxicity/biological pathways will be necessary to apply MOA as the organizing principle.
Identification and representation of biological toxicological pathways will be done using software such as Ingenuity Pathway Analysis (http://www.ingenuity.com/), Cytoscape (Saito et al. 2012), and Impala (Kamburov et al. 2011).
However, here we would also like to identify those probes that become increasingly downregulated, which, in turn, would help us to identify significantly dysregulated biological pathways (as members of the pathway will be either up or downregulated).
We predict that use of antisense ASOs in combination with small molecule therapeutics against the target protein encoded by the antisense-targeted mRNA, or an alternate target in the same or a connected biological pathway, will likely be the most beneficial application of this emerging class of therapeutic agent.
The new pathway will be costly.
Repeat the activity and the pathway will be reinforced.
Biological pathway analyses will be used to inform analyses of the relationship between multiple exposures and child health.
A biological pathway will remain at steady state until occurrence of external perturbation.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com