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Information from gene sets representing biological pathways were obtained from REACTOME (Croft et al., 2011), which are also provided in the Molecular Signature Database (Subramanian et al., 2005).
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Gene sets from GO, BBID (Biological Biochemical Image Database), Biocarta, and Kegg pathways were obtained from DAVID Bioinformatics Resource (http://david.abcc.ncifcrf.gov).abcc.ncifcrf.gov
No biological pathways were enriched by upregulated proteins in responders.
Summary: Manual curation and validation of large-scale biological pathways are required to obtain high-quality pathway databases.
We hypothesized that ncRNAs and coding genes belonging to the same biological pathways are likely coordinately regulated.
Biological pathways are important for understanding biological mechanisms.
However, the underlying biological pathways are only partially understood.
Again, no under-representation of any biological pathways was found.
Furthermore, the most enriched biological pathways are related to signaling.
The 49 biological pathways are given in Table 3.
Three independent biological replicates were obtained for comprehensive gene expression profiling of the adult RPE.
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