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Using GO enrichment analysis, multiple biological pathways were found to be significantly enriched for differentially expressed genes (FDR < 0.01), including cholesterol and sterol synthesis, system development, and cell differentiation.
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Again, no under-representation of any biological pathways was found.
In contrast to the strong transcriptional responses elicited by the heat and starvation, no significant enrichment of biological pathways was found under plant defensive stress, likely due to the low overall number of DE genes.
The enriched GO biological processes and pathways were found mainly related to regulation of cell death, apoptosis, cell proliferation, and metabolic process, which have been proved essential to cancer development.
Several biological processes and signaling pathways were found to be strongly correlated with HCC metastasis.
A total of 15 different metabolic pathways were found (Table 5), of which some were consistent with biological processes that already revealed by GO analysis.
A total of 200 different metabolic pathways were found in this study, with some being consistent with biological processes already revealed by GO analyses.
A total of 26 different metabolic pathways were found with more than 3 genes affiliated, of which some were consistent with biological processes already revealed by GO analyses.
GO biological processes (BP) and KEGG pathways are found in clusters related to "steroid and sterol metabolism", "carbohydrate metabolism" and "biosynthesis of fatty acids and amino acids".
More intriguingly, we found that the in silico predicted biological pathways were similar between CA and AAs although their miRNA expression profiles were different.
We found that seven of the top ten identified GO-associated biological pathways were related to developmental processes (not shown).
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