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This would be bleak news for those who argue that the common variants detected so far, even if they explain only a small percentage of the risk, will nonetheless identify the biological pathways through which a disease emerges, and hence point to drugs that may correct the errant pathways.
This could suggest the presence of multiple biological pathways through which the variants influence the two phenotypes.
Comparisons of risk factor breast density associations with corresponding established risk factor breast cancer associations may shed light on the biological pathways through which risk factors operate.
The specific biological pathways through which alcohol consumption interacts with the cardiovascular system are not always clear, but several mechanisms have been identified that may play a role.
Examination of different dimensions of social engagement suggests that we can identify more precise biological pathways through which social engagement influences cardiovascular disease.
One of the several hypothesized biological pathways through which air pollution may increase cardiovascular mortality is by alterations of the cardiac autonomic function (Kwon et al. 2001; Pope et al. 2004; Routledge and Ayres 2005).
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Chu 2007 et al., in their review explain that the biological pathway through which obesity affects the labour process is not well understood [ 52].
However, because of limited evidences from experimental/toxicological studies, the biological pathway through which short-term exposure to PM2.5 and its components affects health is still an area of active investigation, and the mechanisms for long-term exposure are less understood.
Each TCM herb may contain various ingredients and involve several biological pathways through its interactions with numerous genes, which could be supported by one or many literature evidences; and these interactions may help in the discovery of new therapies for diseases.
We then connected diseases to biological pathways through overlapping genes.
Moreover, this model represents the biological pathways through a set of reaction equations without showing their relation to the biological functions creating the pathway.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com