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This network contributes to the investigation of drug-activated biological pathways that regulate phenotypic changes in cells.
In this study, we examine the interrelationship between PPI network topology and both known and newly identified biological pathways that regulate melanogenesis.
Lack of progress in combating the high mortality and morbidity associated with severe sepsis, in part reflects our limited understanding of the complex biological pathways that regulate innate immunity (Riedemann et al, 2003; Goldenberg et al, 2011).
The circadian genes may affect cancer susceptibility through effects on biological pathways that regulate DNA damage and repair, carcinogen metabolism and/or detoxification, cell growth and cell death [ 35].
In the future this method may be used to place targets identified in RNAi screens within the context of known biological pathways that regulate the system under study, deriving additional relevance from systems-level RNAi datasets.
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However, recent work suggests that one biological pathway that regulates permeability involves zonulin.
Knowledge concerning the subcellular localization of proteins is important for providing insights about protein function and the intricate pathways that regulate biological processes at the subcellular level.
(3) It can help our understanding of the intricate pathways that regulate biological processes at the cellular level [1], [2] and hence it is indispensable for many studies in system biology.
Information of the subcellular localization of proteins is important because it can (1) indicate how and under what kind of cellular environments they interact with each other and with other molecules, (2) provide useful clues for revealing their functions, and (3) help understand the intricate pathways that regulate biological processes at the cellular level [1], [2].
In general, genes cooperate with other genes as some parts of pathways that regulate specific biological processes.
It is well known that cells undergo a variety of biological responses when placed in hypoxic conditions, including activation of signaling pathways that regulate proliferation, angiogenesis and death.
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