Sentence examples for biological pathways that could from inspiring English sources

Bearing this in mind, we report the use of GSEA to generate hypotheses about dysfunctional biological pathways that could be driving proliferation and contributing to the poor outcome of the tamoxifen-treated, highly proliferative (luminal-B) ER+ BC subtype.

Nevertheless, these findings change our understanding of the biological causes of Wilms' tumours and will help identify the biological pathways that could be targeted in different subgroups of tumours for therapeutic purposes.

This approach was used to identify significant biological processes and pathways that could be shared between targets of miRNAs of interest.

To obtain a global view of the altered biological functions and canonical pathways that could be responsible for intrinsic resistance in cervical cancer, we performed functional analysis in IPA.

Using Genecodis software, we searched for co-occurrence of functional annotations corresponding to GO biological processes or KEGG signaling pathways that could potentially be ascribed to specific subsets of the induced or repressed genes listed in Additional file 1: Table S1.

Secondly, these two SNPs were chosen based on the known biological plausibility linking these SNPs to underlying pathways of sepsis or pathways that could affect the mechanisms of action of DAA.

In this review, we discuss the biological rationale for combination therapeutics, review some existing combination drugs and present a systematic approach to identify interactions between molecular pathways that could be leveraged for therapeutic benefit.

The ToxCast data set provides a rich resource for identifying chemically induced changes in biological pathways that are associated with in vivo end points and that could potentially lead to human disease.

Understanding the regression process in vivo could help identify the biological pathways that will facilitate tumor growth arrest and drive the tumor to complete regression.

Finally, identifying novel biomarkers could also point to new biological pathways that may play a role in early dementia and identify druggable targets and endophenotypes for genetic studies.

We found that lower bsDNA overestimates methylation, and, using higher bsDNA amounts, we confirmed a previous report of higher methylation of THBS2 in clear cell OC, which could provide new insight into biological pathways that distinguish OC histological types.