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Additionally, gene set enrichment analysis (GSEA, version 2.0) and Ingenuity Systems software (Ingenuity Systems, Redwood City, CA, USA) were applied to reveal biological pathways modulated by rat transgene or age.
We further analyzed the HDACi-DEGs to explore the key biological pathways modulated by HDACi treatment.
Lastly, although we previously established biological plausibility and proposed biological pathways modulated by statin therapy, it is possible that these pathways are not the ones involved in the development of acute organ failure [ 7, 9].
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Our global exploratory approach identified biological pathways modulated along with PIP expression, providing further support for its good prognostic value of disease-free survival in breast cancer.
Although the relative contribution of furan mediated alterations in metabolic pathways and antioxidant defense to the overall toxic response to furan, including considerations of dose and time, remains to be established, our work contributes to mapping biological processes and toxicity pathways modulated by reactive electrophiles.
A schematic diagram in Fig. 7 shows the metabolic pathways modulated by UDCA treatment.
PTEN is also expressed in neurons, and pathways modulated by PTEN can influence neuronal function.
RNA sequencing (RNA Seq) was applied to identify genes and pathways modulated by PKC agonists.
It is possible that some colon cancer cells have acquired oncogenic addiction to AMPK or one or more of the pathways modulated by AMPK.
This analysis clearly identifies signaling pathways among the most relevant pathways modulated by L. major promastigotes.
Canonical pathway analysis revealed Notch signaling as the most significant signaling pathway modulated by estradiol.
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