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Testing the aggregation of genetic variants, in particular biological pathways, may be more powerful.
Those common biological pathways may be controlling generalized responses to injury and repair which cannot distinguish the type of lung injury across different models.
Still, the fact that progesterone seems to act on many different biological pathways may be cause for hope, said Geoffrey Manley, a neurosurgeon at the University of California, San Francisco, one of the centers involved with the new trial.
This first report of an association between ADAM33 and psoriasis confirms that common biological pathways may be involved in the etiology of psoriasis and other clinically distinct immune-mediated diseases.
Distinct expression patterns in two sets of patients suggest that different biological pathways may be active.
Biological pathways may be considered to be complex control systems, which medicine tries to manipulate to achieve desired results.
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This is a substantial property in the analysis of microarray data, because the understanding of the biological pathway may be improved by the identification of an entire set of correlated genes [5].
Additional applied immunoinformatics frameworks include the statistically powerful weighted gene co-expression network analysis (WGCNA), whereby novel biological modules and pathways may be discovered [ 61], as well as ontology-based methods to define novel biomarkers and infer biological functions [ 62].
Biological and psychosocial pathways may be responsible for observed associations.
Since pathways are essentially integrated circuits that actualize specified biological processes, perturbation of pathways may be harmful to regular biological systems.
While it makes biological sense that genes involved in similar pathways may be affected in opposite manners, subgrouping was performed a posteriori for clarity of the figures using a splitting criterion based on up- or down-regulation.
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