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In the sections below, we recount examples that illustrate the process of disease discovery and how it can, in turn, provide new information about the role of genes and biological pathways in normal and impaired physiology.
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Since their discovery, microRNAs have become prominent regulatory candidates, providing missing links for a few biological pathways in this process, although their exact role in human normal embryo formation and endometrial preparation for pregnancy remains unclear (Galliano and Pellicer, 2014).
Our study links biological pathways in ccRCC using gene array and pathway analyses of patient-matched normal renal and ccRCC tissues.
There are four options: (1) Pathway: biological pathways in KEGG PATHWAY, (2) Brite: protein classifications in KEGG BRITE, (3) Process: biological process terms in GO, and (4) Function: molecular function terms in GO.
Juhila, J. et al. MicroRNA expression profiling reveals miRNA families regulating specific biological pathways in mouse frontal cortex and hippocampus.
Lettre, G. et al. Identification of ten loci associated with height highlights new biological pathways in human growth.
Different types of light affect various biological pathways in plants.
GO enrichment analysis of URDEGs revealed significant alterations in various biological pathways under normal conditions as well as under water stress conditions.
Are degrees of controllability of the biological pathways different between normal and abnormal Cells?
In turn, knowledge regarding the cause of such impairments may further our understanding of the biological pathways that underpin normal language acquisition [ 7].
Owing to the natural functions of cortisol in regulating mammary gland biology, its misregulation and prolonged presence during periods of stress is likely to expose breast cells to the activation of downstream biological pathways outside their normal context.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com