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137 Accordingly, biological pathways are represented by directed graphs, where nodes are biological compounds and the edges represent catalytic or inhibitory regulatory.
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Next, the researchers used systems-level computer analyses to overlay the identified genes onto known molecular networks to see which biological pathways were represented.
Biological pathway are represented by means of graph diagrams.
The nodes that have genes that are enriched in a particular biological pathway are represented on the right side of each tree.
The pathways were represented as Boolean functions of biological processes, delivering an interactive scheme to organize enriched information with an emphasis on involvement of biological processes in pathways.
Six biological groupings were associated with the MEN, with a predominance of immune-related and cellular signalling pathways being represented.
(D) Biological pathways that are represented in significantly downregulated genes.
To remedy this problem, Arcadia recognizes that diagrams representing biological pathways are not merely generic graphs, but conform to a number of context-specific stylistic conventions that aid their legibility.
Subramanian and colleagues [ 32] have described a method that analyzes whether or not predefined gene sets (representing biological pathways) are coordinately and significantly upregulated or downregulated between samples that represent different biological or clinical entities [ 32].
Biological pathways are important for understanding biological mechanisms.
Information from gene sets representing biological pathways were obtained from REACTOME (Croft et al., 2011), which are also provided in the Molecular Signature Database (Subramanian et al., 2005).
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