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Microarray based assessment of ApoB siRNA mediated effects revealed a number of differentially expressed genes which mapped onto biological pathways and processes related to lipid and cholesterol metabolism.
"We were amazed at the diverse range of biological pathways and processes that all genes fell into," such as energy, autoimmunity and sex hormones, Perry said.
By comparison, little is known about interactions between higher order biological systems, such as biological pathways and processes.
However, this still did not clarify which biological pathways and processes are affected in the GHR mutant mice.
The array does not cover the full transcriptome, but many biological pathways and processes are represented and they did not exhibit any detectable seasonal variation.
We have also conducted a comparative transcriptomics study on ESCs, which examined a large set of biological pathways and processes, as well as transcription factors and growth factors expressed in ESCs [12].
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"We believe this will help reveal specific biological pathways and developmental processes that are affected in autism," Noonan said.
In total, 185 human sulfenylated proteins showed homology to sulfenylated plant proteins and the conserved sulfenylation targets participated in specific biological pathways and metabolic processes.
A consensus regarding the affected biological pathways and molecular processes has also started to emerge.
"Ingenuity" pathway analysis was used for functional analysis on the set of significantly modulated genes to identify affected biological pathways and functional processes.
Transcription factors are of particular interest given their ability to control the expression of numerous genes, and thus their ability to regulate biological pathways and developmental processes.
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biological machines and processes
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biological pathways and delineates
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biological pathways and cascades
biological pathways and phenotypes
biological pathways and mechanisms
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biological pathways and networks
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biological structures and processes
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