Our network of human traits based on ∼ 2,300 genes, ∼ 1,200 biological pathways and 800+ phenotypes is more comprehensive than that of previous studies.
These models provide fundamental insights into biological pathways and often display phenotypes that are similar to clinical manifestations of the corresponding disease in humans, providing an opportunity to decipher mechanisms of disease pathology as well as develop therapies.
Currently, genome-wide association studies increasingly identify the contribution of multiple genetic loci to phenotypes by providing clues as to the biological pathways and interactions involved.
Some loss-of-function mutations generate dramatic phenotypes in model systems, and these mutations have been pivotal to understanding biological pathways and molecular mechanisms for human diseases.
Biological pathways and their cluster.
Biological pathways and networks of protein interactions are key paradigms to link molecules to biological functions and by so doing bridging the genotype-to-phenotype gap as well as understanding properties of the organization of biological matter [ 10- 13].
Our approach to predict novel indications by representing disease-drug combinations as combinations of their molecular and mechanistic features, including biological processes, pathways, and phenotypes, not only led to the proposal of drug repositioning candidates but also allowed mechanistic insights into them.
The RGD provides several types of disease-focused data, including genetic and genomic data, as well as information on biological pathways, phenotypes, and individual strains.
Herein, this method reflected the compound's effects on the biological pathway and correlated to the phenotype data which could provide different opinions on pathway based virtual screening.
