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We demonstrate that cross-species correlation of transcriptional changes that occur upon ESC differentiation is a powerful predictor of ESC-important biological pathways and functional cores within a pathway.
We therefore implemented GSEA [ 52], an algorithm that is designed to effectively evaluate the effect of a specific experimental condition on known biological pathways and functional categories.
A thorough collection of gene expression summaries are provided, inclusive of patient demographics, disease subclasses, regulated biological pathways, and functional classifications.
"Ingenuity" pathway analysis was used for functional analysis on the set of significantly modulated genes to identify affected biological pathways and functional processes.
Identification of a large number of differentially regulated genes in each germination phase enables the studies to identify biological pathways and functional groups that are transcriptionally up-regulated or down-regulated at a systems level using MapMan and PageMan tools.
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To make biological sense of the findings from NGS data will require computational, biological, and clinical analyses to link the biological pathways and the functional relevance of the molecular alterations to NPC, and to evaluate the associations of genomic changes with NPC diagnosis, prognosis, and treatment strategies.
Although common genes are rarely reported, biological pathways and even more so functional classes tend to overlap between studies [ 40].
Our knowledge about molecular interaction networks, functional biological pathways and transcriptional regulatory modules is rapidly expanding, and is being organized in lists of functionally related genes.
Future studies should include information on functional biological pathways and gene variants associated with severe obesity.
This association of AuNPs with RNA or RNA related protein machinery emerged again when we examined enrichment of biological pathways and gene ontology (GO) based functional enrichment (Supporting Information, Figure S7).
Changes in biological pathways and gene ontologies were assessed via functional enrichment analysis, using the GenMAPP [ 24] and MAPPFinder [ 25] softwares (University of California at San Francisco, San Francisco, CA).
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biological studies and functional
biological features and functional
biological pathways and therapeutic
biological networks and functional
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biological insights and functional
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biological pathways and HRG-regulated
biological interactions and functional
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biological pathways and physiological
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biological materials and functional
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