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Recently we developed a bioinformatic environment called Eu.Gene [22] containing a repository of all the freely available biological pathways and different statistical methods dedicated to analyze expression datasets and assess for enrichment in biological pathways.
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In order to check rigorously the claims of convergent biological pathways and processes for different gene lists, we examined (see Methods) the two most established outcome prediction signatures, the 70 gene list of van't Veer et al. [7] and Wang et al's ER+ signature [33].
Studies performed so far in vitro on the adrenergic receptors have suggested that different haplotypes might regulate selective biological pathways and physiological responses to different stimuli [12].
In fact, even for strains closely related to S288c, the small number of sequence differences may still have important consequences for different biological pathways and phenotypes.
However, little is known about how CNVs alter biological pathways and how this varies across different populations.
The method relies on the functional classification of proteins into different biological pathways and processes and on full proteome comparisons between the putative model organism and other organisms for which we would like to extrapolate results.
Through this approach we tried to assess the interactions of known T2D candidate genes with other molecules in different biological pathways and a few unique interactions which could result in new, non-obvious hypotheses that are statistically significant.
Intrinsic resistance and acquired resistance may involve different biological pathways, and thus, a solution for one resistance type may not apply to the other.
The "gold standard" genes all have known functions, come from at least five different biological pathways, and are distributed in various cellular compartments.
Physiological levels of ROS are required for proper functioning of different biological pathways and in maintaining homeostasis within the human body.
We also set out to assess the accuracy of the participants' predictions regarding different biological pathways and to test which gene expression regulatory processes (biological pathways/functions) were translatable and therefore predictable across species.
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CEO of Professional Science Editing for Scientists @ prosciediting.com