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Complex traits typically involve diverse biological pathways and are shaped by numerous genetic and environmental factors.
Together, these results indicated that many disease associated genes are related to each other in the form of biological pathways and are consistent with the modular view of disease genes [8], [11].
The SERPINs are a family of serine proteases involved in a spectrum of biological pathways and are of particular relevance to the coagulation pathway.
The "gold standard" genes all have known functions, come from at least five different biological pathways, and are distributed in various cellular compartments.
As molecular coordinators, the tetraspanins are involved in many fundamental biological pathways and are correlated with the malignant process and prognosis (Lazo, 2007).
However, poor overlap among gene sets may not be as serious a problem as previously thought if different gene sets represent similar biological pathways and are congruent on outcome prediction [ 30- 32].
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However, the pathogenesis of metabolic disorder and its chronic complications involves multiple biological pathways and is largely unknown.
Phosphorylation can either activate or inactivate biological pathways and is commonly used to switch enzyme activity "on" or "off".
It turned out that the regulated gene sets generally identified groups of genes that functioned in a similar biological pathway and were generally accurate in assigning regulators to sets of genes whose functions were consistent with the regulators' known roles.
ODEs are a common method of modeling biological pathways and have been used to model a range of signal transduction processes [29], [33] [41].
Problems of context are barriers to the reliable function of biological pathways, and they are often intermixed with problems of robust and modular circuit design.
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