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With the assistance of two signal transducers (gold nanoparticles and acid base indicators) or pH meter, the outputs of the biological network could be conveniently read by the naked eyes.
From these data it is possible to take some considerations: 1. it is possible to speculate that the male germ cell representation as a biological network could be an important tool, because it would allow to study not only the molecular components of these cells, but also their intracellular localization and intermolecular interactions in signaling pathways.
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The simulation model of biological networks could be differed according to the specification of nodes in a system.
For Ingenuity Pathways Analysis, we used a Fisher's exact test to calculate a p-value to determine the probability that the biological function assigned to that network could be explained by chance alone.
Because we know very little about the genotype networks of biological circuits, we cannot say whether the enhanced capacity for exaptation that is conferred by a large genotype network could be realized by extant biological circuits.
Three high scoring networks could be identified.
Thus, by a scale-free network model, a new biological function could be acquired or lost by a TU almost arbitrarily with or without selection pressure.
We believe that our system biological approach could be useful for identifying other complex networks mediating immunological responses.
Close biological relationships could be established between most genes using gene network analysis.
A biological pathway could be seen as an area of densely connected genes in a functional gene network.
The biological meaning of the identified network structures could be achieved by selective manipulation of neuronal pathways by electrical or optogenetic stimulation linked to the ECoG array by neurofeedback, or neuropharmacological manipulations.
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