Beginning with a scene from "Frankenstein," it is filled with ominous images of grim know-it-all doctors in white coats, elaborate diagrams of family trees, and disturbing pictures of the deformed and mentally ill, photographed to look like monstrous biological mutations.
The artist explains, "This sort of evolution, as it evokes biological mutations from a phenomenon of interbreeding that erases the distinction between human and animal, foresees new forms of life- born from the hybridization of gender and species- as a natural thing in this future's cyborg society".
In particular, it makes possible to distinguish true biological mutations from sequencing errors, facilitating assembly of rare individual genomes.
However, errors produced by most sequencing protocols complicate distinguishing between true biological mutations and technical artifacts that confound detection of rare mutations and rare individual genome variants.
In contrast to clonal samples, the post-sequencing error correction methods are not well suited for mixed viral samples and may lead to filtering out true biological mutations.
Post-sequencing error-correction techniques are available for reads obtained by regular protocol offering the possibility to partially correct sequencing errors trading off for real biological mutations.
Similarly, users can introduce biological mutations to simulate loss-of-function and gain-of-function experiments while watching the dynamics of the cell change as a result of the mutations.
We also found that patients carrying the MLL-rearranged or BCR-ABL fusion gene, two crucial biological mutations associated with poor outcome, expressed lower levels of miR-100 and miR-99 compared with patients without these two fusion genes.
Furthermore, this approach requires no biological mutations or chemical treatments to the biomaterial itself; hence, it is widely applicable and the compact devices also allow samples to be analyzed at the point of need.
