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Hydrogen sulfide (H2S), as a novel gaseous messenger molecule, plays an important role in signal transduction and biological modulation.
Very recently, a novel mode of biological modulation of internalization of targeted nanocarriers has been described.
Pre-clinical studies have demonstrated the biological modulation of 5-fluorouracil by methotrexate and leucovorin.
Further knowledge about the relationship between these potent enzymes and rotator cuff degeneration may also be valuable for potential biological modulation of the system.
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Radio sensitivity depends on intrinsic factors, defined by genetic determination as well as on extrinsic factors like growth receptor signalling and their chemical or biological modulations [ 8].
The biological modulations of FGF-2 on MMP13 and ADAMTS5 were abolished in the presence of either the FGFR1 inhibitor (P < 0.05) or the FGFR1 neutralizing antibody (P < 0.05).
Additionally, since a single miRNA can regulate numerous target mRNAs within biological pathways, modulation of a miRNA in principle allows for influencing an entire gene network and modifying complex disease phenotypes (van Rooij & Olson, 2012).
Whereas clinical measurements might be relatively insensitive for assessing structure-modifying capacities, and radiological evaluations require longer-term follow-up, it is tempting to hypothesize that the evaluation of biological immuno-modulation by TNF-α blockade might provide additional evidence for a disease-modifying effect in SpA.
Although most synthetic polymers were initially considered inert, certain polymers can influence multiple cellular processes, especially when combined with biologically active agents, primarily through interactions with biological membranes and modulation of gene expression profiles.
Vitamin A is an essential micronutrient that regulates many biological processes through modulation of retinoic acid receptor-responsive genes, acting as a systemic antioxidant and participating in the modulation of diverse redox mechanisms involved in physiological and pathological processes.
In addition to biological regulatory mechanisms, modulation of entropy can also be controlled by environmental factors, such as changes in temperature, redox-potential and pH.
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