The final network models reflect the value of the combined use of molecular profiling data with careful considered use of prior biological knowledge of cause-and-effect relationships The network models were built to represent an extensive body of published literature and datasets.
The use of biological heuristics is a flexible strategy, which utilizes prior biological knowledge of the system to design queries.
Demonstrates basic knowledge of causes SI.4.
Electronic repositories of biological knowledge [ 35, 36, 49- 55] and expert knowledge of the modeling team were also helpful.
Difficulties in the efficient construction of engineered circuits often stem from a lack of biological knowledge.
Often, biological knowledge consists in descriptions of mechanisms and processes.
Thus, many mathematical models have been developed through the accumulation of biological knowledge [21].
Biocuration has become an essential aspect of biological knowledge dissemination.
Deriving a standard from these hierarchies is further complicated due to varying levels of biological specificity of curated biological knowledge.
The main advantage of such methods over single gene based methods is that they directly link the ranked gene list with biological knowledge and therefore provide better functional insight into the cause of the phenotypic differences under study.
