We also propose a clinical and biological interpretation of mediated interaction using three hypothetical examples.
Finally, 48 spots (listed in additional file 6: Supplemental table S1) were kept for the biological interpretation of our results, including ten spots (#1183, #1210, # 1292, #1324, #1325, #1409, #1500, #1547, #1554, #1759) corresponding clearly to degradation products of Rubisco (a major soluble protein in all plants).
These data may be analysed ignoring the fact that some individuals are healthy and others diseased, however this potentially leads to misleading results if the statistical properties of the trait (variance, heritability, etc) differ between the two subpopulations, or if the biological interpretation of the indicator trait differs between the two subpopulations.
Figure 2 illustrates the biological interpretation of CSF results according to three methods.
A biological interpretation of the data was performed using two types of analysis to identify the main biological functions and the main metabolic pathway disorders revealed by the expression profile of the PSSM muscles.
A biological interpretation of the data was performed using two data-mining programs to identify the main biological functions and the main metabolic pathway disorders revealed by the expression profile in EPO-d muscles.
The biological interpretation of this observation (i.e. variants in two linked genes) is not straight-forward; however, both SLC22A4 and IL13 are putative genetic risk factors for other autoimmune or autoinflammatory disorders.
A comparative biological interpretation of our obtained supertree and the topology of other two trees also favors the Super3GL result.
Hence, from these two profiles associated with each principal component, biological interpretation of each one of these components can be inferred [ 35].
On two real data sets, we provide a thorough biological interpretation of the results obtained and compare the inferred statistical networks to known biological networks using data knowledge driven analyses.
