They are established resources for clinical geneticists, neurologists, and researchers in need of comprehensive, referenced genetic, epidemiologic, clinical, neuropathological, and/or cell biological information of specific gene mutations in these diseases.
The GO annotation format allows curators to associate biological information to specific forms of a protein, so wherever the published evidence allows, the UniProt GO annotation set includes specific isoform and post-translationally modified protein data, using UniProtKB isoform and feature chain identifiers.
Thus, further refinements of these assays may provide biological information regarding specific subsets of OPN species in cancer, whether generated by alternative splicing [ 40] or post-translational modification, including proteolysis.
This situation has prompted us to propose and develop a novel computational approach that integrates disparate biological information and predicts specific pathways (defined group of proteins that are organized in a specified order and perform a specified biological task or function) and their organization.
This can be achieved using proteomics in combination with other postgenomics technologies, such as lipidomics or microRNA profiling as well the integration of biological information in disease-specific networks for CVD.
Further, different effects of RNA quality on specific ontological categories can complicate the extraction of biological information from microarrays of varying quality.
Although recent genome-wide screens have generated abundant data on quantitative fitness for single gene knockouts, very few studies have systematically integrated other types of biological information to understand how and why deletion of specific genes give rise to a particular fitness effect.
Finally, many signalling pathways, including activation of p53 [ 32], involve post-translational modifications such as protein phosphorylations, deacetylations, and so on, meaning that information relevant to changes in biological function of specific proteins is not reflected in altered mRNA expression.
These network reconstructions serve as manually curated knowledge bases of biological information as well as mathematical representations of biochemical components and interactions specific to each organism.
This strategy allows the identification of epitopes with a specific expression profile (e.g., tumor-specific), independently of any biological information.
This framework describes the distributions of reaction fluxes that are compatible with constraints that derive from basic physical assumptions or specific biological information.
