However, the biological implication of this are being challenged and suggest a more complicated mechanism for sirtuin protein regulation of p53 in vivo [5].
To further validate the biological implication of this scoring method, we compared the cellular microarray results of serially diluted CD4 T cell lines with IFNgamma production in a parallel control experiment, in which the same numbers of T cells were seeded into a 96-well plate coated with peptide:MHC and anti-CD28/CD11a anti-CD28/CD11ariod ofortheulation (Figure 3).
The biological implication of this equation is that the measured gene expression level g k is modeled by the effect of transcription, controlled by 5′ cis-acting elements.
Although the exact biological implication of this phenomenon is still unknown, it is proposed to be a fail-safe mechanism to eliminate cells with extensive DNA damage (Nigg and Stearns, 2011).
The biological implication of this change is that ER-α, c-MYC and (MEK1 or AKT1) proteins should act together to make the cells pass through S-phase and proliferate.
A histone deaminase function has also been recently reported for intracellular LOXL2 (linked to heterochromatin (Herranz et al., 2012; Millanes-Romero et al., 2013)), but the biological implication of this new LOXL2 enzymatic function is not yet fully understood.
