KLK5 has biological functions that include degrading desmosomal proteins and inducing proinflammatory cytokine secretion through protease-activated receptor 2 (PAR2).
In addition, the ECM also serves additional biological functions that include interaction with embedded cells and regulation of the activity of other extracellular molecules.
Proline has many biological functions that include acting as an energy source, antioxidant and osmoprotectant [ 37, 38].
These genes are associated with a range of biological functions that include bacterial motility and attachment, stress tolerance, virulence, regulation, transport, multidrug resistance, detoxification and signal transduction.
This analysis revealed that HI0628 controls expression of genes associated with a range of biological functions that include bacterial motility and attachment, stress tolerance, virulence, regulation, transport, multidrug resistance, detoxification and signal transduction.
Functional genomics has particular promise in silkworm biology for identifying genes involved in a variety of biological functions that include: synthesis and secretion of silk, sex determination pathways, insect-pathogen interactions, chorionogenesis, molecular clocks.
We searched Affymetrix NETAFFX for "GO [gene ontology] biological functions" that included "cellular migration".
Gene enrichment and functional annotation analysis revealed that the 282 differentially expressed probes in the Per35/5 hypothalamic tissue were significantly associated with biological processes and molecular functions that included terms linked with neuronal development and signaling, as well as the regulation of transcription (Supplemental Fig. S1 C).
The MCODE algorithm identifies highly connected regions of biological networks representing clusters of related function that include protein:protein interaction complexes [ 49].
In the CN, biological functions that were DE included those involved in oxidative metabolism, ion transport, cellular regulatory processes, and immune response.
As shown in Table 1, the top biological functions that are significantly affected includes neurological disease, host cell death and survival, cellular growth, proliferation and migration, host immune response, cell-cell interaction, nervous system development and function, gene expression, cell movement as well as cell signaling.
