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These observations indicate that PPP1R2 pseudogenes have possible biological functions rather than acting as non-functional relics as initially believed.
In the SIF model, stochasticity is induced at the level of biological functions rather than at the level of expression of a protein/gene.
A critical consideration is what metrics to translate; quantifying fundamental aspects of biological functions rather than representing them by phenomenological parameters seems necessary.
Furthermore, it supports the importance of focusing on the actions of drugs on cellular processes and biological functions rather than on a single molecule in a pathway.
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This resulted in many immune-based diseases being categorized and treated by medical specialists based on tissue location and biological function rather than by the underlying cause of the disease (Dietert, in press).
In conclusion, ICPs provide a quantitative annotation that captures the subtle biological behavior of diverse proteins and functions, rather than providing classical "all or nothing" scores to distinguish between true and false positives.
Radiopharmaceuticals reflect physiologic and pathologic functions rather than anatomical abnormalities.
We reasoned that an effective biological antiviral device should be based on essential viral function rather than on a specific protein with a defined sequence or tertiary structure that is targeted by chemical inhibitors or antibodies.
Our results suggest that, even when the shape of the benefit function is unknown, biological public goods should be modelled using a sigmoid or step function rather than a linear or concave function.
Clearly identifiable mutations in protein-coding regions represent a more tractable situation for biological experimentation, given the broader toolkit currently available for interrogating protein function rather than gene regulation.
When completed, FLEX will emphasise function, rather than structure.
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