Recently, light has been used as a trigger to control the biological function of small molecules, oligonucleotides, and proteins involved as parts in gene circuits.
The molecular interaction and, hence, the biological function of a small molecule is related to its three-dimensional structure when interacting with the protein.
Therefore, the goal of this study isto identify the transcriptomic composition and biological functions of CSCs from non-small cell lung cancer (NSCLC).
Of the 23 genes in Cluster 1, IPA created a single network from 14 members with the top biological functions of Infectious Disease, Cell Signaling, and Small Molecule Biochemistry (Table 3).
Overall, these results suggest that miR-148a influences the tumor progression-related biological functions of cancer cells by regulating a small subset of cancer-relevant genes within its regulated PIN.
To date, little is actually known about the biological functions of most miRNAs the roles of only a small number have been experimentally elucidated [6], [7].
In order to identify putative biological functions of the EBOV genes and protein-binding small molecules, it is first necessary to determine the functional sites and domains of the encoded proteins.
The biological functions of the affected proteins include stress responses (small heat shock proteins HSP22, HSP27), housekeeping (GARS, glycyl tRNA synthetase), protein glycosylation in the ER (seipin), RNA processing (immunoglobulin μ-binding protein 2 [LGHMBP2] and senataxin), and axonal transport (dynactin).
However, relatively small numbers of reports have been showing biological functions of lncRNAs because of lacking full-length sequence and structural data of lncRNAs.
