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The biological functions of human neutrophil proteinase 3 (Premainmain unclear because of its close structural resemblance to neutrophil elastase and its apparent functional redundancy with the latter.
RECQ1 helicase is the most highly expressed of the human RecQ helicases; however, a genetic disease has yet not been linked to mutations in the RECQ1 gene, and the biological functions of human RECQ1 in cellular DNA metabolism are not known.
As a general conclusion of this analysis, we can say that KEGG pathways is revealed as a good database to investigate the biological functions of human genes, because it includes groups of genes that really work together in well defined biomolecular processes.
Here we review recent progress on our understanding of the biological functions of human ncRNAs and their clinical potential.
Meanwhile, numerous genes, including WT1, GATA4, GATA1, GDNF, BMP4, SCF, FGF2, EGF, FHSR, AR and ABP, essential factors produced by Sertoli cells, were stably expressed during the long term culture of Sertoli cells, suggesting that our culture system has little effect on the expression profile and biological functions of human Sertoli cells.
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To evaluate the effects of low molecular weight heparin (LMWH) and heparin-binding epidermal growth factor (HB-EGF) on the biological function of human trophoblast in first trimester.
The biological function of human ovaries declines with age.
We show that the biological function of human SERF1a originates from its atypical ability to specifically distinguish between amyloid and nonamyloid aggregation.
The in vivo biological function of human DUX4 is still unknown, although a number of groups are addressing this question using experimental approaches based on exogenous expression of DUX genes[ 19- 21].
The comparison is additionally useful because the biological functions of many human homeobox genes were inferred through analysis of orthologues in mouse.
We also developed an algorithm to uncover the biological functions of the human lung cancer miRNA-TF synergistic regulatory network (regulation of apoptosis, cellular protein metabolic process, and cell cycle), and the specific functions of each miRNA-TF synergistic subnetwork.
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