miRNAs regulate various biological functions including developmental timing, cell proliferation, neuronal cell fate, apoptosis (reviewed in [12], [13]), neuronal gene expression [14], brain morphogenesis [15], muscle differentiation [16], and stem cell division [17].
Chemokines, a family of structurally-related cytokine molecules, exert diverse biological functions including control of angiogenesis.
The genes affected help to govern broad and important biological functions, including stress, the immune system, inflammation, metabolism, and circadian rhythms.
Macrophages carry out a wide variety of biological functions, including participation in neovascularization [9].
Hematopoietic cells are endowed with very specific biological functions, including cell motility and immune response.
Affected biological functions included the sub-groups "Diseases and disorders", "Physiological system development and function" and "Molecular and cellular functions".
Through these diversity of functions, CCN1 modulates important biological processes including developmental processes, angiogenesis and tissue regeneration, and plays a role in pathological conditions such as wound healing, vascular diseases, inflammation, fibrosis and tumor development [ 10, 11].
Although the biological functions of most miRNAs are not yet fully understood, they may have a key role in the regulation of various biological processes, including developmental timing, cellular differentiation, proliferation, apoptosis, gene regulation, insulin secretion, cholesterol biosynthesis and cancer development.
Puf proteins have extensive structural conservation within their RNA binding domain and regulate a range of biological processes, including developmental patterning, stem cell control, and neuron function [ 3].
miRNAs have been reported to be involved in many biological processes, including developmental timing, differentiation, proliferation, cell death, and metabolism [10], [11], [12].
