Lipids execute a variety of biological functions including cell signaling, energy storage, and maintenance of compartmental boundaries.
Integrins transmit bidirectional signals across the plasma membrane and regulate many biological functions, including cell differentiation, migration, growth, and survival.
Hematopoietic cells are endowed with very specific biological functions, including cell motility and immune response.
Fibronectin is a multifunctional glycoprotein that mediates a number of important biological functions including cell adhesion and migration [48].
The fibroblast growth factor (FGF) family is composed of 22 members with a wide range of biological functions, including cell growth, development, angiogenesis, and wound healing [1] [7].
GO entities involved in important biological functions including cell cycle, DNA repair and microtubule cytoskeleton genes were highly overexpressed (Table 5 and [7]).
A number of additional biological functions including, "cell-cell signalling and interaction" (86/235), "cellular growth and proliferation" (111/235) and "cellular movement" (65/235) were enriched.
p53 is the most extensively studied tumour-suppressor gene, encoding a sequence-specific transcriptional regulator that controls a plethora of biological functions, including cell-cycle progression, senescence, differentiation, DNA repair, and apoptosis (Vogelstein et al, 2000; Oren, 2001, 2003).
Identified biological functions included cell cycle (859 genes, p-value = 9 10−41), gene expression (1231 genes, p-value = 6 10−34), cellular growth and proliferation (1188 genes, p-value = 8 10−34) and cell death (1658 genes, p-value = 8 10−32).
Our selected biological functions included cell cycle checkpoint, innate immune response and negative regulation of translational initiation, which all have been extensively reported to be related to HCV infection.
Receptor Tyrosine Kinase (RTK) signalling pathways regulate a wide range of biological processes and functions, including cell survival, growth, differentiation and migration [1].
