HA is naturally present in almost all body fluids and tissues such as the synovial fluid, eye vitreous humor, connective, epithelial, and neural tissues and plays important biological functions in wound healing regulating cell adhesion, motility, differentiation, and proliferation.
In addition, Synoviolin ubiquitinates and sequesters the tumor suppressor p53 in the cytoplasm, thereby negatively regulating its biological functions in transcription, cell-cycle regulation and apoptosis by targeting it for proteasomal degradation.
Thus, CD16+ and CD16- Mo express distinct transcription factors that may differentially regulate biological functions in vivo.
Matricellular proteins are a set of non-structural extracellular matrix (ECM) proteins, mainly including thrombospondins (TSPs), OPN, tenascins, SPARC, POSTN and CCNs, which do not exert a primary role in tissue architecture but regulate similar biological functions in response to external stimuli during embryonic development, tissue injury, inflammation and tumor progression (Bornstein, 1995).
These results suggest that CCN proteins might regulate common biological functions in chondrosarcoma.
In mammals, there are seven Sir2 homologues called sirtuins (SIRT1-7), which regulate various biological functions in aging, metabolism and disease.
MiRNAs regulate various biological functions in normal cells such as growth and differentiation, and they are increasingly recognized as playing critical roles in cancer development and progression.
A well-studied miRNA, the miR-21, has been shown to be overexpressed and to regulate several biological functions in OSCC [ 16, 18– 20].
The result showing that these target genes were enriched for the functions on cell cycle and immune response supports the notion that miRNA can regulate such biological functions in the asthmatic response.
Glutamine regulates many biological functions in preserving the cell, acts as a key respiratory fuel and nitrogen donor for rapidly dividing cells, and modulates the expression of many genes associated with metabolism, cell defences and repair, and cytokine production.
